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KMID : 0387720070180010056
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Korean Journal of Blood Transfusion
2007 Volume.18 No. 1 p.56 ~ p.60
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A Case of Rifampin Induced Hemolytic Anemia Combined with Thrombocytopenia and Acute Renal Failure
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Ko Chi-Seon
Kwon Kye-Chul
Park Jong-Woo
Koo Sun-Hoe
Shin So-Yeon
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Abstract
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A 35 year old woman was admitted to the hospital owing to her nausea, vomiting, oliguria and petechia with re-administration of rifampin. Laboratory tests were performed and they showed a hemoglobin level of 8.6 g/dL, a leukocyte count of 7,660/μL, a platelet count of 1,000/μL, a blood urea nitrogen level of 92.3 mg/dL and a creatinine level of 10.6 mg/dL. The Direct Coombs’ test and anti-platelet antibody test were positive. Hemolytic anemia combined with thrombocytopenia and acute renal failure related to rifampin was suspected. We proved the formation of immune complex with anti-rifampin antibody and rifampin by in vitro testing. Hemolytic anemia combined with thrombocytopenia and acute renal failure after treatment with rifampin is a rare condition. We report here on such a case along with a brief review of the related literature.
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KEYWORD
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Rifampin, Hemolytic anemia, Thrombocytopenia, Acute renal failure
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